ABSTRACT
Background: The study was conducted to understand the clinical solution of renal cell carcinoma. Correlation was done by clinical presentation with radiological features and histopathology of renal cell carcinoma. The stress upon to understand the necessity for a team-approach between Clinician, Radiologist and Pathologist and vice versa is emphasized. Aim: Histopathology and Clinical Correlation of Renal cell carcinoma. Methods: The total number of renal tumours studied during the 8 years period was 45 cases among which 25 cases were diagnosed by histopathology as various types of renal cell carcinoma conclusively. This is a retrospective study of renal tumours, diagnosed by histopathology as various types of renal cell carcinoma. All the relevant clinical data of the patients were searched from the ward records. The various Radiological features were collected. Results: The total number of renal tumours studied during the 8 years period was 45 cases among which 25 cases were diagnosed by histopathology as various types of renal cell carcinoma conclusively. MRI provides molecular information with regard to renal cell carcinoma and potentially aid in biopsy planning. The total cases reported in the department is twenty five vases out of which sixteen cases are attending follow up after 3 years. Conclusion: The Fuhrman grading of renal cell carcinoma correlated grading of renal cell carcinoma. Preoperative radiological classification can be used as a supplement to the histopathological grading. Renal cell carcinoma needs correlation between Radiologist, Pathologist and Clinician.
ABSTRACT
The study was conducted to understand the clinical algorithm of benign bone tumours. Correlation was done by clinical presentation with radiological features and histopathology features. The osteogenic tumours are considered as one group because their common characteristic feature is the production of an osteoid or bone matrix by the tumour cells. The cartilaginous tumours have the characteristic feature of production of cartilage matrix. AIM: We have reported 62 cases of bone tumours during the study period of 5 years in the Department of Pathology, Thoothukudi Medical College, India. The cases were thoroughly studied by histopathology and 28 cases were diagnosed as benign tumours among which 8 cases were benign osteoid producing and 20 cases were diagnosed as benign cartilage producing tumours conclusively. The Histopathology diagnosis was correlated with the Radiological features. Methods: We have reported 62 cases of bone tumours during the study period of 5 years in the Department of Pathology, among which 28 cases were diagnosed as benign bone tumours. A total of 8 cases were osteoid producing and 20 cases were cartilage producing tumours conclusively. All the relevant clinical data of the patients were searched from the ward records. The data was stored in the Department computer server was very much useful in the study. The initial step in the assessment of patients with bone tumours is a good medical history, including age, gender, type and duration of symptoms, localization of the mass, and presence of a history of trauma. CT scan was useful in osteoid lesions. MRI Scan played a crucial role in cartilage producing tumours. Tests to assess general health included a complete blood count , differential count , tests for serum electrolytes including calcium, magnesium, phosphate, liver function studies, blood group typing, a coagulation profile, tests for hepatitis and human immunodeficiency virus infection were taken and recorded. Results: The total number of benign bone tumours reported during the 5 years period was 28 cases,. In benign bone tumours osteochondroma was the most common neoplasm. CT scan established the best choice in studying cortical lesions and nidus in osteoid osteoma. CT can identify the calcification of cartilage. In cases of cartilage producing tumours, the T2 weighted MRI with high signal intensity with a lobulated outline made a useful role. MRI can delineate the medullary extent. Multinucleated giant cells were seen in sections of chondroblastoma. Histopathology provided the final conclusive diagnosis. Conclusion: Benign bone tumours frequently pose a diagnostic challenge for general surgical pathologists. Accurate pathologic diagnosis requires careful clinical, radiological and histopathological correlation. The most common benign bone tumour occurring in children is osteochondromas, representing 10 to 15% of all bone tumours and 20 to 50% of all benign bone tumours.
ABSTRACT
Plants produce a diverse range of bioactive compounds making them rich source of different types of medicines. The plants are mostly cultivated for decoration and to enhance the appearance of houses, gardens, road sides, and also for commercial purposes such as floral decorations in form of bouquet. They are also source of fragrant oils for perfume making and cosmetic. However only very few of these plant species have found to be used in medicine and little or no literature exit on their chemical and biological activities. Araucaria columnaris is an ornamental plant, commonly known as Christmas tree, belonging to the family Araucariaceae. Plant resin was used for the present study, antibacterial activity and GC-MS analysis of Araucaria columnaris resin was carried out. The resin was subjected to solvent extraction using decreasing polarity solvents (aqueous, methanol, ethyl acetate and benzene). TLC profiling of all the extracts gives an idea about the presence of various phytochemicals and its fractions were checked for antibacterial activity against major clinical pathogens. It was found that fraction 4 (F4) of methanolic extact showed maximum zone of inhibition against Gram positive organisms. This fraction was subjected to GC-MS analysis; the result revealed the presence of a board range of many medicinal compounds and antioxidant activity of resin of Araucaria columnaris were identified.